Abstract In this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition.Specifically, we focus on the spontaneous ability of cells to bypass or override this checkpoint, referred to as checkpoint adaptation.Some factors involved
Animals may be subjected to various stressors during transport, which may compromise their health and welfare as well as meat quality.In the chain of operations between a farm and a slaughterhouse, animal transport is probably the most stressful and injurious stage.Data on mortality is commonly collected at slaughterhouse as a retrospective indicat
Summary: Graphdiyne (GDY) as an emerging 2D carbon-network nanomaterial Energy Support possesses many fascinating properties that lead to numerous exciting applications, but the use of GDY and its derivatives in the antibacterial field has not yet been discovered.In this study, we first report on the use and evaluation of GDY and graphdiyne oxide (
Cellular activation in trans by interferons, cytokines, and chemokines is a commonly recognized mechanism to amplify immune effector function and Books limit pathogen spread.However, an optimal host response also requires that collateral damage associated with inflammation is limited.This may be particularly so in the case of granulomatous inflamma